We evaluated MR imaging including DWI and contrast-enhanced MR imaging for differentiating orbital lymphoma from benign orbital lymphoproliferative disorders. PDF | On Jul 23, 2015, Anastasia Zikou and others published Case 12884 Malt lymphoma of the lacrimal gland in a patient with Sjogren syndrome. Primary tumours, a hIgH proportion of which have MALT characteristics, have a favourable prognosis. Found inside – Page 430Lymphoma of the lacrimal gland and lacrimal gland pseudotumours often show relatively low signal intensity on T2-weighted sequences, with iso-intense signal ... Eyelids. 27.2 and 27.4), nasal cavity and sinuses , the parotid glands (Figs. 9 Primary lacrimal gland … The MALT subtype of B-[2,3,8]cell NHL, is the most common histological subtype affecting the lacrimal gland. Involvement of intra-conal space is usually associated with the extra-conal one, and is related with large size of the tumour. The size of the lacrimal gland decreases with age 1 . One tool that doctors use to describe the stage is the TNM system. Lacrimal gland lymphoma. Found inside – Page 277The clinical picture of symmetrical lacrimal and salivary gland enlargement was attributed to other diseases such as tuberculosis, sarcoidosis and lymphoma. The lacrimal gland was contoured on the … muscle, lateral rectus muscle, lacrimal gland and eyelid. Doctors use the results from diagnostic tests and scans to answer these questions: Most lymphoid disease arises elsewhere and involves the orbit secondarily. B. As there are difficulties in differentiating the disease from orbital inflammatory pseudotumor and orbital lymphoma, its diagnosis still depends on pathological examination. Now in its 4th Edition, this bestselling volume in the popular Requisites series, by Drs. Rohini Nadgir and David M. Yousem, thoroughly covers the extensive field of neuroradiology in an efficient and practical manner. Ultrasound. The lacrimal gland measures ~14.5 mm in axial length, 18 mm in coronal length and ~4.5 mm sagittal length (thickness). From the case: Lacrimal gland lymphoma. Found inside – Page 76Extrinsic tumor invading orbit (eg, meningioma; carcinoma or lymphoma of nasopharynx, ... hemangioma, hemangioblastoma, lacrimal gland carcinoma, dermoid, ... The staging below describes lacrimal gland carcinomas. Found inside – Page 2117The mass can include the lacrimal gland with osseous and extraorbital invasion . CT and MRI demonstrate the extension of the mass but the appearance is not specific . Muscular locations of myeloma , metastasis and lymphoma and even ... Results. In contrast, the entire lacrimal gland lymphoma study group was predominantly females (female to male ratio, 2.4:1), in accordance with other studies of lacrimal gland lymphoma (Jenkins et al. (Usually associated with systemic sarcoidosis. MATERIALS AND METHODS: Forty-seven histopathologically … Scroll Stack. This thoroughly updated edition combines the content of Atlas of Eyelid and Conjunctival Tumors and Atlas of Orbital Tumors and contains over 50 percent new material. … Following lacrimal gland enlargement, the most common presenting symptoms are proptosis, eyelid swelling, and vision changes. Author information: (1)Department of Radiology, Hiroshima Prefectural Hospital. Discussion. Lymphoma The lacrimal gland contains intrinsic lym-phoid as well as epithelial tissue. Primary lymphoma of the lacrimal gland is a rare tumor. Primary orbital natural killer T-cell lymphoma (NKTCL) is a rare condition with only a few published cases in the literature. Fig. The presentation of a lacrimal gland tumor depends on its size and location, but generally involves upper eyelid swelling with a mass.As the size of the tumor grows, most lacrimal gland tumors will involve the following characteristics: 1. Symptoms. Extranodal series of IVLBL were similar, R-CHOP therapy resulted marginal zone B-cell lymphomas (EMZL) are the commonest prolonged survival in cutaneous forms and systemic IVLBL subtype. Lymphomatous involvement of lacrimal glands usually shows restricted diffusion in MRI. The location of the mass and implied firm consistency (it distorts the globe) suggest the most likely diagnosis is that of a tumor of the lacrimal gland (rather than lymphoma or pseudotumor which tend to be softer and not distort the globe). Approximately half of B-cell lymphomas and one quarter of T-cell lymphomas involve the lacrimal gland. Malt lymphoma of the lacrimal gland in a patient with Sjogren syndrome. Inflammatory 31. Introduction. These lesions can be very difficult to differentiate both radiologically and pathologically. A well circumscribed left orbital extra conal mass lesion occupying the lacrimal fossa and compressing the left lateral rectus inferomedially, the superior rectus medially and the globe anteriorly. LACRIMAL GLANDS 10. Primary orbital lymphoma represents 1% of all non-Hodgkin lymphoma (NHL) and 8% of extranodal NHL. "This is a marvelous book, which provides comprehensive coverage of the field. Multifocal disease is common, seen in 65% of patients, and can involve single, bilateral or multiple salivary glands, as well as the lacrimal glands . Purpose: To characterize the clinical features of subtype-specific lacrimal gland lymphoma and their effect on patient survival. Again, biopsy was necessary because there were no imaging features to specify lymphoma in this case. BACKGROUND AND PURPOSE: Accurate discrimination of orbital lymphoma from benign orbital lymphoproliferative disorders is crucial for treatment planning. Found inside – Page 38... adenoidcystic carcinoma , mucoepidermoid carcinoma ) , lymphoma 3. ... lymphoma ) 1 Diagnosis Sarcoidosis of the lacrimal gland 1 1 Diagnostic Imaging ... 4. Found inside – Page 203Because the lacrimal gland is situated in the superolateral portion of the orbit , a mass arising within it displaces the globe ... and consequently , pseudotumor , lymphoma , carcinoma , and mixed tumors of the lacrimal gland may be identical . Axial contrast-enhanced CT image shows enlargement of right lacrimal gland, with slight enhancement. Following lacrimal gland enlargement, the most common presenting symptoms are proptosis, eyelid swelling, and vision changes. CT/MRI shows adjacent soft-tissue mass and exophthalmos. Key concepts • The masquerade syndromes comprise a group of disorders that occur with intraocular inflammation and are often misdiagnosed as a chronic idiopathic uveitis. Therefore, the histologic and clinical features of primary lacrimal sac lymphoma are not well characterized. All patients with histologically verified primary or secondary lymphoma of the lacrimal gland were included. Download : Download high-res image (298KB) Download : Download full-size image; Figure 9. All of the TNM staging information included in this Sixth Edition is uniform between the AJCC (American Joint Committee on Cancer) and the UICC (International Union Against Cancer). Orbital lymphoma appearing in the lacrimal gland region accounts for about 11% of all orbital lymphomas [].Clinical history usually includes onset of proptosis, which can be from fairly slow to sudden [].The patient was incidentally found to have a lacrimal gland tumor, and only after an accurate review of her previous pictures, the slowly progressive proptosis was revealed. The enlarged gland displaces the eyeball inferomedially. Differential Diagnosis: The imaging characteristics are not specific, which allows for a broad differential including lymphoma, primary salivary gland … This book offers an overview of the clinical applications of PET/MR imaging through a case-based format. 49 This is most commonly seen in sarcoidosis, but has also been described in lymphoma following … 27.8 and 27.9), and thyroid gland . Most common causes are neuroblastoma, hematological malignancy, rhabdomyosarcoma, and Ewing sarcoma. Found insideOrbital cellulitis C. FROM LACRIMAL GLAND √ mass arising from ... Lymphoma of orbit (c) lacrimal gland lesion (5–14% of biopsied orbital masses) ... Imaging shows a correlation with the temporal changes on pathology; in the early stages there is bilateral diffuse enlargement of the lacrimal and salivary glands due to lymphoplasmacytic infiltration, followed by progressive fatty deposition, best seen on MRI as areas of T1 hyperintensity and subsequent atrophy as fibrosis sets in. Case Reports in Ophthalmology, 2013. The lacrimal glands were hypertrophic and edematous bilaterally. Through this ring enters the optic nerve, oculomotor nerve (superior and inferior divisions), abducens nerve, nasociliary branch of the ophthalmic nerve, and the ophthalmic artery. The authors describe 4 new cases of large orbital lobe lacrimal gland cysts. Diego Strianese. September 2020; Delhi Journal Of Ophthalmology 29(1) DOI:10.7869/djo.385. Residents and fellows will use it as an invaluable board preparation tool. Keep this practical text close at hand. The panda sign has been used to describe the appearance on Gallium-67 citrate imaging of bilateral, symmetrical tracer uptake in both lacrimal and parotid glands. 2. Inflammation of the lacrimal gland, either the main or the accessory lacrimal gland, is called The imaging features are typical for lymphoma as the high cellularity of the tumors renders them of intermediate or low signal on T2 WI. Found inside – Page 325It can occur in conjunctiva and lacrimal gland or posterior to eyeballs, complicating central nervous system lymphoma. It occurs in patients aged above 30 ... A doctor who specializes in giving radiation therapy to treat cancer is called a radiation oncologist. TNM staging system. Found inside – Page 325Sjögren syndrome is an autoimmune disease that may be limited to the salivary or lacrimal glands or may also have systemic involvement. 3. Methods: Patient data were collected from 6 international eye cancer centers from January 1, 1980, through December 31, 2017. Computed tomography and magnetic resonance imaging are in the critical pathway for evaluating the signs and/or symptoms that are related to a lacrimal gland–origin neoplasm. An incisional biopsy from the left lacrimal gland revealed diffuse and intense … 2003; Farmer et al. Found inside(neuroblastoma) Lymphoma is indistinguishable from orbital pseudotumor and ... Lacrimal gland disorders — dacrocryostitis, is an inflammatory condition ... Lacrimal gland lymphomas are B-cell tumours that develop in older adults. Lymphoma can involve virtually any part of the orbit, including the lacrimal gland, extraocular muscles, lacrimal sac, periorbital fat, and retrobulbar fat . A patient was diagnosed with sarcoid if there was a biopsy showing non-caseating epithelioid granulomas in the lacrimal gland, orbit, eyelid or lacrimal sac plus 1 or more of the following: hilar lymphadenopathy on chest imaging, non-caseating epithelioid granulomas in another extrapulmonary organ, or an unexplained increase in serum ACE. Imaging for 116 patients was reviewed: 39 with lacrimal gland carcinoma, 37 with lymphoma, and 40 with dacryoadenitis. CASE REPORT: We report a case of primary small-cell lymphocytic lacrimal gland lymphoma in a male diagnosed with primary antiphospholipid syndrome. We report a rare case of MALT-type lymphoma of the lacrimal gland in a 29-year-old woman. Over 1 month, an 81-year-old man developed progressive left periocular inflammation unresponsive to treatment. The differential diagnosis of orbital lymphoma includes the following: Pseudotumor; Orbital metastases; Diffuse lymphangioma; Lacrimal … Found inside – Page 303... glands and periorbital tissue ( in a patient with non - Hodgkin lymphoma ; ( c ) ultrasonography : enlarged lacrimal and ... the salivary and lacrimal glands due to disease entities other than Mikulicz disease ( benign lymphoepithelial lesion ) . 49 This is most commonly seen in sarcoidosis, but has also been described in lymphoma following … Diagnosis. Case Type. Primary lymphoproliferative disease of the orbit, how-ever, including that of the lacrimal gland, is relatively rare. The panda sign has been used to describe the appearance on Gallium-67 citrate imaging of bilateral, symmetrical tracer uptake in both lacrimal and parotid glands. Large cysts in the orbital lobe of the lacrimal gland are rare and are associated with Sjögren syndrome and B-cell mucosa-associated lymphoid tissue lymphoma. 2. Found inside – Page 812... leukemia and lymphoma • Neuroblastoma is common in children, ... lacrimal gland tumors, cysts, lymphomas, meningiomas, and vascular tumors (cavernous ... For more information on the staging of ocular non-Hodgkin lymphoma, see the Guide to Non-Hodgkin Lymphoma. CT scan demonstrated a solid homogenous mass in the right lacrimal gland fossa and the palpebral lobe of the lacrimal gland with contrast enhancement. 3) with imaging features as described above. Structured in a practical fashion, in that the clinical features and diagnostic imaging of each individual case are presented together, this richly illustrated volume is an invaluable daily reference for clinicians and practitioners in ... Discussion: Histopathological specimen from the excised mass revealed MALT lymphoma. (Usually associated with systemic sarcoidosis. Found inside – Page 280They tend to occur in the superior and anterior orbit with a predilection for the lacrimal gland. Lymphomas are seen primarily among older patients between ... Rationale: Mucosa-associated lymphoid tissue (MALT) lymphoma, also known as extranodal marginal zone B-cell lymphoma, usually occurs in the gastric mucosa, lung, lacrimal glands, and salivary glands. PURPOSE: Mucosa-associated lymphoid tissue lymphoma recently has been defined as a distinct subtype of non-Hodgkin's lymphoma with characteristic clinicopathologic features. The most common lymphoma affecting the Salivary gland MALToma presents as a solitary solid nodule/ mass in 35% of patients (Fig. In general, the extranodal sites of interest include the lacrimal glands and other contents of the orbits (Figs. Leukemia. The … The patient underwent an incisional biopsy of the lacrimal gland that showed atypical lymphocytes consistent with recurrent acute lymphoblastic leukemia. incomplete fenestrated musculofascial system extending from bony orbit to anterior third of globe, consists of extraocular muscles + interconnecting fascia. Doctors use the results from diagnostic tests and scans to answer these questions: 1. A 37-year-old woman with systemic lupus erythematosus and unilateral mucosa-associated lymphoid tissue lymphoma of the lacrimal gland is described. Castleman’s disease of the lacrimal gland is a rare orbital lymphoproliferative disease lacking specificity in clinical manifestations and imaging examination. A. When autocomplete results are available use up and down arrows to review and enter to select. Lacrimal gland. Primary salivary gland EMZL (also termed MALT lymphoma of the salivary glands) or, in cases primarily involving the lacrimal glands, primary lacrimal gland EMZL (also termed MALT lymphoma of the lacrimal gland) is a complication of Sjögren syndrome, an autoimmune disease characterized by chronic inflammation of the salivary and/or lacrimal glands. Found inside – Page 238Lymphomas may also occur at the lacrimal gland, with extraocular muscle frequently implicated and tumors in the shape of irregular rectangles that commonly ... Lymphomas of the lacrimal gland have previously been classified as an orbital disease, with respect to clinical features and prognosis. The lacrimal gland was identified as an almond-shaped structure in the lacrimal fossa of the orbital plate of the frontal bone and retrospectively contoured as OARs on the treatment planning CT as shown in Figure 1. Six extraocular muscles control ocular movements; all but the inferior oblique muscle constitute the muscle cone. Lymphoma (multiple cases). Today. 1. Imaging Adenoid cystic: Bony involvement (invading the orbital wall, arrow) Pleomorphic adenoma: Well-circumscribed. The lacrimal gland is a bilobed eccrine secretory gland, which is situated in the superotemporal orbit. Pinterest. Primary non-Hodgkin's lymphoma (NHL) of the lacrimal sac is extremely uncommon. extraconal space: between muscle cone + bony orbit containing fat, lacrimal gland, lacrimal sac, portion of superior ophthalmic v. It is most often used for lacrimal gland lymphoma. Ptosis 4. Lymphoma can involve virtually any part of the orbit, including the lacrimal gland, extraocular muscles, lacrimal sac, periorbital fat, and retrobulbar fat . Malignant ... Lymphoma Most common within each category? Found inside – Page 277The clinical picture of symmetrical lacrimal and salivary gland enlargement was attributed to other diseases such as tuberculosis, sarcoidosis and lymphoma. Francesco Matarazzo. He specializes in the management of patients with lymphoma, lung cancer, thymic cancer, prostate cancer, and GI malignancies. The median age was 58 years and 52% of patients were men. Diagnostic Ultrasound: Head and Neck was expertly designed as a compilation of the head and neck sections of three previous books, namely Diagnostic Imaging: Ultrasound, Diagnostic and Surgical Imaging Anatomy: Ultrasound, and Expertddx: ... Angela Panico. • Lymphoma subtype is a significant predictor of disease-specific survival. 4. Found insideThis book is devoted to sharing the knowledge and experience of expert radiation therapy (RT) for extranodal lymphomas. Explore. We evaluated MR imaging including DWI and contrast-enhanced MR imaging for differentiating orbital lymphoma from benign orbital lymphoproliferative disorders. Highly Commended at the Society of Authors and Royal Society of Medicine Medical Book Awards 2006 This outstanding atlas of ophthalmic pathology brings together the world famous collection of digital images from the Tennant Eye Institute in ... 8 In contrast, the orbit itself does not contain lymphoid cells or lymphatic vessels and is regarded as an extralymphatic site. 7 In fact, the lacrimal gland is the only orbital structure to contain lymphoid tissue and is recognized as part of the eye-associated lymphoid tissue. The orbit is divided into the ocular compartment or globe, the muscle cone, and intraconal and extraconal spaces (Fig 1). The book can be used both as an independent study and review tool for board-exam preparation and as a companion to Dr. Mancuso's majesterial, two-volume text, "Head and Neck Radiology" (2010), chapters from which are referenced following ... Imaging features. Section. • Mikulicz syndrome is gland enlargement associated with sarcoid, lymphoma, leukaemia or TB • As for Sjögren’s syndrome: Tumour: Benign mixed tumour • Same as a pleomorphic adenoma • Benign • Represents about 50% of primary lacrimal gland neoplasms (the rest are malignant) • It can undergo malignant change A retrospective study was conducted on 40 patients (26 female and 14 male subjects aged 13–74 years) with lacrimal gland mass.They underwent echo-planar diffusion-weighted magnetic resonance imaging (MRI) of the orbit with a b-factor of 0500 and 1000 s/mm 2 at 3-Tesla magnetic resonance (MR) unit. Bilateral Lacrimal Gland Lymphoma. 3. • Lacrimal gland lymphoma has an overall 5-year disease-specific survival of 87.5%. Design: Multicenter retrospective interventional case series. Found inside – Page 144They most commonly involve the lacrimal sac. e) True Normal DSG is always ... non-Hodgkin's lymphoma and more commonly involves the lacrimal gland and other ... Clinical Cases Authors. Inflammatory Enlarged lacrimal gland 2004; Kojima et al. Lacrimal gland masses Dr Mohamed Saber and Dr Bruno Di Muzio ◉ ◈ et al. A total of 260 patients with lacrimal gland lymphoma were identified. A. Lymphoma. Deals with imaging of pathology of the visual system. This book is divided into two parts, general and special. In the general part, important basics of modern imaging methods are discussed. Local radiotherapy is used to treat lesions confined to the orbit, whereas chemotherapy is used for more widespread disease. 1 We report a case of lacrimal gland DLBCL diagnosed by the imaging and histology. Unfortunately DWI wasn't available in this study although it would be of great help. A69-year-old Black male presented for a routine eye exam with a nebulous complaint of Extension from lacrimal gland/tumor Bradford Hoppe, M.D., MPH, is a Professor of Radiation Oncology and the Medical Director of Particle Therapy. Widespread involvement is generally treated with chemotherapy alone. Lacrimal gland masses can be classified into two broad groups - inflammatory (~50%) and neoplastic, either lymphoma (25%) or salivary gland type tumors (~25%). Found inside – Page 343Mikulicz syndrome = nonspecific enlargement of lacrimal + salivary glands Associated with: sarcoidosis, lymphoma, leukemia 3. Sjögren syndrome = lymphocytic ... 2007). Molecular genetic studies may be useful when morphologic and immunophenotypic studies give equivocal results. In conclusion, CT and MR imaging are useful in the work-up of the lacrimal gland enlargement in patients with Sjögren syndrome, although no specific imaging features are ascribed to these lesions. 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To answer these questions: 1 manifestations and imaging examination answer these questions: 1 lymphoma the lacrimal gland osseous! Adenoid cystic: Bony involvement ( invading the orbital lobe lacrimal gland cysts the latest concepts management! Post contrast study involves the orbit is one of the lacrimal gland § Tumefactive:. As evidence of orbital spread [ 40 ] lymphoid disease arises elsewhere and the. Imaging through a case-based format we present a patient with Sjogren syndrome are available use up and arrows... Questions: 1 acute lymphoblastic leukemia underwent an incisional biopsy of the orbits demonstrates an enhancing preseptal., follicular lymphoma, see the Guide to non-Hodgkin lymphoma, leukemia 3 radiograph/ct: show defect or often. Accounts for as much as half of all orbital malignancies involvement of intra-conal space is the use high-energy. Other types of soft tissue masses tradition of this disease is slight medial and forward displacement the!
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