To understand the pathophysiological details of PD and for developing and screening the novel therapeutic and/or neuroprotective substances, animal models for PD induced by neurotoxins have been developed. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. Written in the Neuromethods series format, the chapters provide authoritative reviews of many commonly used approaches in the field today. Found insideParkinsons disease is a disabling neurological condition with both motor and non-motor symptoms for which no cure is available at this stage. This book is unique in covering the most important topics related to Parkinsons disease. At present, there are several neuroprotective therapies in the experimental pipeline, but these are for the patients of tomorrow. This book focuses on two therapies that are readily available for the patients of today. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, mol Found inside – Page iiThe collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. Found inside – Page iiThis book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures. This book gives a comprehensive overview on current clinical and basic research issues related to Parkinson’s disease and its related disorders. Fourteen experiments (Chapters 1-5 below) were conducted to investigate two potential animal models of Parkinson's disease. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the ... This textbook aims to tell the full story of non-motor and non-dopaminergic features of Parkinson's Disease. Found insideComprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the ... Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. This book encompasses developing an understanding of the principles underlying the advent of novel molecular approaches to neurological and neurosurgical diseases. This book addresses various aspects of this class of drugs from their chemical development to their clinical use. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders. This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. Found inside – Page iiAuthoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new ... Found insideThis book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. Found insideBerlin, Sept. 18, 1828 Alexander von Humboldt To the IWCN aficionado, it may come as a little surprise that this is the pub lication of the 10th Winter Conference as this might mean that they must have missed number 9. One consequence of the ageing population is a higher risk of certain neurodegenerative disorders. In order to prevent these, we need to learn more about them. One way to do this is to mimic the diseases using animal models. This detailed book focuses on cutting-edge methods for Parkinson’s disease (PD) research, such as the analysis of the prion-like properties of α-synuclein, mitochondrial functions related to the PINK1-Parkin pathway/CHCHD2, the ... The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models ... Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize ... This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for ... Found insideThe surface of the human body and its mucous membranes are heavily colonized by microorganisms. Our understanding of the contributions that complex microbial communities make to health and disease is advancing rapidly. The present essay gives a brief survey of the clinics and pathophysiology of PD, discusses the different animal models of PD currently available, and briefly compares the suitability the rodents and primates as models for human PD. An authoritative collection of recent breakthroughs in Parkinson's Disease (PD) research, Parkinson's Disease: Genetics and Pathogenesis spans key findings on the mechanisms of neurodegeneration and the role of specific genes that may lead ... Volume II of this detailed collection contains sections on the basal ganglia, neo- and allo-cortical systems, cerebellar and brain stem systems, as well as spinal cord systems. During the natural history of Parkinson's disease (PD), many patients require hospital admission for medical or surgical problems other than the motor features of PD. Therefore, they are often admitted to non-neurological wards where the ... This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism. Found insideThis book contains 12 chapters divided into two sections. Section 1 is "Drosophila - Model for Genetics. The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. Found insideThe book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to ... Found inside – Page iWith its multidisciplinary viewpoint, this is the ideal companion for medicinal and natural products chemists as well as neuroscientists, biochemists, pharmacologists, neurobiologists, and phytotherapists. Found insideThis book provides up-to-date reviews on current animal models of both HD and PD. These animal models are essential to investigate links between the pathobiology and the behavioral abnormalities associated with these disorders. 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