Safety Study in Puppies: Advantage Multi for Dogs was applied topically at 1, 3 and 5X the recommended dose to 7-week-old Beagle puppies once every 2 weeks for 6 treatments on days 0, 14, 28, 42, 56, and 70. Without treatment, this dog was neurologically normal at 24 hours and had a normal appetite by 48 hours post-dosing. Do not get in eyes or on clothing. 1. Do not contaminate water, food or feed by storage or disposal of Advantage® II. Store at temperatures between 4°C (39°F) and 25°C (77°F), avoiding excess heat or cold. Works for: Dogs and puppies at least 7 weeks of age. Advantage topicals will not protect your pet from ticks-- K9 Advantix for Dogs, however, does protect against ticks. In a controlled, double-masked, field safety study, AdvantageMulti for Dogs was administered to 128 dogs of various breeds, 3 months to 15 years of age, weighing 4 to 157 pounds. Remove the tube from packaging and open it by putting the cap on the other end and twisting to break the seal. There is no expiration date required on the packaging by the EPA for Advantage® II for dogs. Select your pet to receive relevant content. Select one or more newsletters to continue. Never place unused product down any indoor or outdoor drain. New fleas that jump on the dog from the surroundings, such as grass, carpet and pet bedding, are killed within 2 hours with protection against further infestation for at least 4 weeks. Advantage Multi is applied to your dog’s skin once a month. And by killing eggs and larvae, you can break the flea life cycle. Collagen is not a magical supplement, and it does not work a miracle overnight. Advantage is a spot-on solution that is easy to apply and kills fleas on contact, so fleas don’t have to bite to die. Unlike chewable forms of flea prevention, Advantage® II is applied topically and kills flea eggs, flea larvae and adult fleas through contact with your treated dog. Advantage Multi™ for Cats (10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. Some flea and tick medications take quite a long time to become effective, but others can bring your dog or cat relief within just a couple of hours! CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian. However, we suggest bathing your dog before applying Advantage. Cats up to 9 pounds – 0.4 ml. salivation, dilated pupils, incoordination. 1 card / 6 doses per card (0.8 mL tubes) — 08891446. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Learn how to apply this easy-to-use, odorless topical for dogs once per month to prevent fleas, flea larvae, flea eggs and chewing lice. Oral Safety Study in Beagles: Advantage Multi for Dogs was administered once orally at the recommended topical dose to 12 dogs. How do I store and dispose of Advantage® II? So here is a detailed discussion on all of these with studies. How long does Advantage® II for dogs last? application sites for two (2) hours after application. 4. You can easily place an order on our website in under 5 minutes. This is temporary and does not affect the safety and effectiveness of the product. Freedom of Information Summary: NADA 141-251. However, reinfestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer … 2. Prevents and treats: Kills fleas at multiple life stages. When replacing another heartworm preventative product in a heartworm prevention program, the first treatment with Advantage Multi for Dogs should be given within one month of the last dose of the former medication. For consumer questions call 1-800-255-6826. Flea Treatment: For the treatment of flea infestations, Advantage Multi for Dogs should be administered at one-month intervals. Prior to administration of Advantage Multi for Dogs, dogs should be tested for existing heartworm infection. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Feb 14, 2015. Do not have contact or allow children to have contact with the area treated with Advantage® II for dogs until completely dry. Generic Name: imidacloprid moxidectin solution Cats 10+ pounds – 0.8 ml. So fleas do not have to bite your dog to die. Twist the cap to break the seal and then remove cap from the tube. Your dog is free to take a dip after Advantage® II has been on for 24 hours. Another dog exhibited abnormal neurological signs (circling, ataxia, generalized muscle tremors, and dilated pupils with a slow pupillary light response) starting at 4 hours post-dosing through 18 hours post-dosing. Advantage Multi® (imidaclopid + moxidectin) Discover how Advantage Multi® has an innovative transdermal formula with imidacloprid + moxidectin for monthly flea protection. For someone who unfortunately has health challenges, glandulars provide nutrients not found in plants and they don’t create any negative reaction that could occur from taking plant material. The signs resolved without intervention by day 10 post-application. Keep in mind that more frequent bathing may keep the product from working the full 30 days. body weight. Increased RBC, hemoglobin, activated partial thromboplastin, and direct bilirubin were observed in the treated group. Pyriproxyfen is an … Do not induce vomiting unless told to do so by the poison control center or physician. Part the hair on the back of the dog between the shoulder blades until the skin is visible. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Unlike chewable forms of flea prevention, Advantage® II is applied topically and kills flea eggs, flea larvae and adult fleas through contact with your treated dog. While the number of circulating microfilariae may decrease following treatment, Advantage Multi for Dogs is not effective for microfilariae clearance. Storage: Store in a cool, dry place. See the Product Label for specific application instructions by weight. Avoid contact with skin. The number of application spots depends on the size and weight of your dog. Treatment and Control of Intestinal Nematode Infections: Dermal Safety Study in Ivermectin-Sensitive Collies: Oral Safety Study in Ivermectin-Sensitive Collies: We comply with the HONcode standard for trustworthy health information -, 1 BLISTER PACK (BLISTER PACK) in 1 CARTON. Advantage Multi for Dogs may be administered year-round or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. How long does Advantage® II for dogs take to work? Do not let this product get in your dog’s mouth or eyes. Bayer, the Bayer Cross and Advantage Multi are registered trademarks of Bayer. For more detailed instructions, watch our application video. Dogs 11-20 pounds – 1.0 ml (Advantage Multi can use this same chart but for dogs only) Dogs 21-55 pounds – 2.5 ml. To further break down the Advantage … At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. Separate treated dogs from one another and from other pets to reduce the risk of accidental ingestion. How Long Does It Take to Receive My Advantage Multi Order? The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration. For dogs weighing more than 20 lbs., place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at 3 or 4 spots on the top of the backline from the base of the neck to the upper back in an area inaccessible to licking. ADVANTAGE AND ADVANTAGE II DOSAGE CHART. However, reinfestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated. Advantage flea treatment for dogs is an easy-to-apply spot-on treatment that kills fleas within one day, preventing further infestations for up to four weeks. The Collies were asymptomatic after ingesting 10% of the minimum labeled dose. Turn the cap over and push the other end of cap onto the tip of the tube. The formula is waterproof so there is no need for reapplication after bathing your dog or taking your pet for a swim. Accidental oral ingestion in dogs caused salivation, vomiting, muscle tremor, seizures, mydriasis, ataxia, lethargy, disorientation, agitation, and poor appetite. Vomiting was seen in one puppy from the 1X treatment group (day 57), in two puppies from the 3X treatment group (days 1 and 79), and in one puppy from the 5X treatment group (day 1). Both Advantage and the new Advantage II last for a full month after application. Advantage flea treatment for cats is applied to your cat’s skin and gets to work quickly, killing existing fleas within one day and re-infesting fleas within an hour and for up to a month. If you choose to bathe your dog in between treatments, we recommend use of a general grooming shampoo for pets. HOW LONG DOES A DOSE LAST? Trifexis is a once a month oral medication. 3. The tablet is beef flavored so your dog should readily accept it as a treat. (See CONTRAINDICATIONS.). Keep out of reach of children. Having and getting rid of fleas can be an unpleasant ordeal for both you and your cat. If the dog is already infested with fleas when the first dose of Advantage Multi for Dogs is administered, adult fleas on the dog will be killed. Puppies younger than 7 weeks of age and pregnant dogs should not use Advantage. Immature flea life stages which live in the pet's environment consist of around 95% of the infestation and can be almost invisible to the naked eye. application sites on themselves or other treated dogs, and. This is true even after baths or swimming, as the Advantage products are waterproof. Advantage ® II for cats combines two active ingredients:. Adverse events reported in dogs topically treated with imidacloprid + moxidectin for dogs included: vomiting, diarrhea, bloody diarrhea, salivation, poor appetite, lethargy, weakness, restlessness, agitation, disorientation, ataxia, muscle tremors, seizures, panting, labored breathing, acute pulmonary edema, hives, rash, swollen face and ears, pruritus, erythema, alopecia, hot spots, local discomfort, and discoloration of the hair at the application site. The Material Safety Data Sheet (MSDS) provides additional occupational safety information. Imidacloprid is a chloronicotinyl nitroguanidine insecticide. Top questions about Advantage® II for Dogs, Unlike chewable forms of flea prevention, Advantage, There is no expiration date required on the packaging by the EPA for Advantage. Yes. Re-infesting or new fleas are killed within two hours for the remainder of the month. The following adverse events were reported in humans: eye irritation, allergic reactions, skin irritation, skin tingling, sore throat, and chemical odor. In avermectin sensitive dogs1, the signs may be Follow label directions for application. A puppy from the 5X treatment group displayed rapid, difficult breathing from 4 to 8 hours following the second treatment. Harmful if swallowed. See product label for additional information. Advantage Multi for Dogs was used safely in dogs concomitantly receiving ACE inhibitors, anticonvulsants, antihistamines, antimicrobials, chondroprotectants, corticosteroids, immunotherapeutics, MAO inhibitors, NSAIDs, ophthalmic medications, sympathomimetics, synthetic estrogens, thyroid hormones, and urinary acidifiers. Advantage spot-on flea treatment for cats contains an active ingredient that works fast, and is able to kill fleas through contact. K9 Advantix ® II kills fleas within 12 hours. Animal Health Division Dogs treated with imidacloprid, including those with preexisting flea allergy dermatitis have shown clinical improvement as a direct result of elimination of fleas from the dog. For dogs weighing 20 lbs. Your dog should be standing for easy application. Whether this actually occurs to a moderately high degree (70-80% flea kills at 28 days) or a really high degree (>90% flea kills at 28 days), however, depends on the study you look at. The dog should be standing for application. more severe and may include coma and death. Advantage Multi ® for Cats and Dogs does have an expiration date that can be found on the bottom edge of the package. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin, in one to four spots depending on your dog’s weight. Part the hair on your dog’s back, between the shoulder blades, until the skin is visible. At 40% of the minimum recommended topical dose, 4 of the dogs experienced neurological signs indicative of avermectin toxicity including depression, ataxia, mydriasis, salivation, muscle fasciculation, and coma, and were euthanized. Ingestion of this product by dogs may cause serious. If a dose is missed and a 30-day interval between doses is exceeded, administer AdvantageMulti for Dogs immediately and resume the monthly dosing schedule. 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