becker muscular dystrophy treatment 2019

Despite childhood onset, independent walking is never lost before the third decade. Therapy & Treatment. Limb Girdle Muscular Dystrophy Type 2i, is one of the rarest forms of this progressive disease. Other aspects of Duchenne and Becker muscular dystrophy are reviewed separately. 0000150129 00000 n Detection of deletions spanning the Duchenne muscular dystrophy locus using a tightly linked DNA segment. Clipboard, Search History, and several other advanced features are temporarily unavailable. H�\�ˊ�0��>E��E�Zۂ��0�y �a�!څo?i~ia�ϓs�O�����&~�A�ibm�K�p��؅���5���O��&]�y'�+�A��������e�Z�m�v��^����1�ԓ�XĊ�5ԺA��y�{b�o[W��wӼv=�_�!�x�q544�Z�����. Exploring the molecular basis for variability among patients with Becker muscular dystrophy: dystrophin gene and protein studies. Investigations. J Neurol Sci 1996;142:70-8. Please enable it to take advantage of the complete set of features! 591 46 2018;1687:31-42. doi: 10.1007/978-1-4939-7374-3_3. 0000110074 00000 n As of 2019, most therapies are supportive in nature, although truly disease-modifying therapies are the subject of intense research. 0000008576 00000 n 0000001638 00000 n Genetic faults in the same gene are also the cause of the more severe form of muscle weakness called Duchenne muscular dystrophy (DMD). BMD can present in several ways such as waddling gait, exercise related cramps with or without myoglobinuria. 2019 Apr;12(2):247-257. doi: 10.1007/s40271-018-0330-8. 0000110802 00000 n How Do Members of the Duchenne and Becker Muscular Dystrophy Community Perceive a Discrete-Choice Experiment Incorporating Uncertain Treatment Benefit? Becker muscular dystrophy is a muscle-wasting condition, first described in 1956, which usually affects only males. However, this is a general biomarker for muscle break down. Translarna can only be obtained with a prescription and treatment should be started by a specialist doctor experienced in the management of Duchenne/Becker muscular dystrophy. Genetic testing will confirm the diagnosis of Duchenne and Becker and show the exact mutation in the gene. J Am Coll Cardiol 1993;22:1927-34. There is no cure for BMD or other muscular dystrophies. 0000005433 00000 n Refer to the specific Health Plan's procedure code list for management requirements. Earl … Update in Duchenne and Becker muscular dystrophy Curr Opin Neurol. Often the first test is a blood test measuring CK (creatine kinase), which is extremely elevated in DMD and BMD. Feb. 11, 2019 — Prednisone, the current standard of care used to treat kids with Duchenne muscular dystrophy (DMD), reduces chronic inflammation but has harsh side effects. Thanks to general medical advances, particularly in cardiology, people with Becker muscular dystrophy (BMD) are living longer in the 21st century than in previous decades. What are the treatments for Becker muscular dystrophy? 0000005999 00000 n h�b``�b``�d`g`��A��؀����Q��a��V��s)�*�@� �n�î�mQ���46�+L8c5=q��‹N��)�*L�r���ew�Ιn� ������ f��iii@��(((��l�pˁ���E��[��J3�h �z�L��L|��@�+�0I3�crb[���s9g#��U�K�C8���BL�0V7�`Pg\��O�O�k~&�͋rtt����"@���3�1�Y5�H�o���fe`P��y�N��q6۵ 100) �[W� It causes muscles to weaken and waste over time, leading to increasing and often severe disability. Becker muscular dystrophy (BMD) is a condition which causes weakness in the muscles. As we look forward to bringing you more news this year, we present the 10 most-read stories of 2019. 10 – “Sarepta Acquires Rights to Novel Gene Therapy Candidate to Treat … 0000024939 00000 n Management includes multidisciplinary care with physiotherapy to reduce joint contractures and prolong walking. BMD is caused by a … 2019 Sep 1;38(3):172-179. eCollection 2019 Sep. Current and emerging therapies in Becker muscular dystrophy (BMD). BMD is caused by dystrophin deficiency due to inframe deletions, mutations or duplications in dystrophin gene (Xp21.2) We review here the evolution and current therapy presenting a personal series of cases followed for over two decades, with multifactorial treatment regimen. Author Information . Keywords: b Department of Pediatrics. 0000020467 00000 n Medical Management. These include use of systemic steroids, early nocturnal ventilatory support, appropriate cardiac care and prophylaxis, and wherever appropriate, scoliosis surgery. 0000076197 00000 n 636 0 obj <>stream 0000006853 00000 n Often children with Becker muscular dystrophy can walk. Author information: (1)Neuromuscular Center, IRCCS San Camillo Hospital, Venice, Italy. In some cases, Becker muscular dystrophy can lead to life-threatening health problems, as heart and breathing muscles weaken. Part II. Yazaki M, Nakamura A, Yoshida K, Ikeda S. Diagnostics (Basel).  |  Generally diagnosed when patients are between two to five years old, it is caused by absence or reduction of the muscle protein dystrophin. Neuromuscul Disord. An Application of Research as an Event.  |  Symptoms generally begin in the teens but may not occur until the mid-20s or even later. 0000024772 00000 n 0000003920 00000 n The mainstay of treatment remains meeting well defined standards of care that have been shown to influence morbidity and mortality. Treatment options include medications, physical and occupational therapy, and surgical and other procedures. However, a variety of treatments help relieve symptoms. 0000115698 00000 n For Immediate … Early interventions may focus on stretching tight muscles (which may initially be the only therapy goal). They have also shown that nearly 50% of the general population in a country suffers from muscle cramps. The patient (Case 1) after cardiac transplantation uses the handrail in descending stairs.…, NLM BMD can present in several … Last weekend, Alex Johnson, Dr David Bull and Megan Mullany represented Duchenne UK at Duchenne Parent Project Onlus’s 17th International Conference on Duchenne and Becker muscular dystrophy in Rome. Eplerenone, a … Waldrop, Megan A. a,b,c; Flanigan, Kevin M. a,b,c. Clinical-molecular correlation in 104 mild X-linked muscular dystrophy patients: characterization of subclinical phenotypes. Myocardial involvement is very frequent among patients affected with subclinical Becker muscular dystrophy. Nature 1985;316:842-5. Registration now open. Last Updated October 23rd, 2019. The evolution is variable. 0000146207 00000 n 0000003081 00000 n Mavrogeni SI, Markousis-Mavrogenis G, Papavasiliou A, Papadopoulos G, Kolovou G. Methods Mol Biol. No. Glucocorticoid treatment and potential disease-modifying therapies for Duchenne and Becker muscular dystrophy will be discussed in this review. 0000001828 00000 n Neuro-Psiquiatr. endstream endobj 635 0 obj <>/Filter/FlateDecode/Index[138 453]/Length 38/Size 591/Type/XRef/W[1 1 1]>>stream Treatments tend to be supportive and include physiotherapy, use of supportive braces, assistive devices, occupational therapy, speech therapy, and in some cases surgery. So … 591 0 obj <> endobj It primarily affects males. -, Melacini P, Fanin M, Danieli GA, et al. -. We have effectively treated over 1691 patients of muscular dystrophy with stem cell therapy in India at NeuroGen BSI. MiRNAs, Myostatin, and Muscle MRI Imaging as Biomarkers of Clinical Features in Becker Muscular Dystrophy. 0000004726 00000 n Beggs AH, Hoffman EP, Snyder JR, Arahata K, Specht L, Shapiro F, Angelini C, Sugita H, Kunkel LM. 0000111099 00000 n Stem cell therapy for muscular dystrophy in India at NeuroGen BSI has come up as a successful muscular dystrophy treatment option after years of research and study. Patient. endstream endobj 592 0 obj <>/Metadata 136 0 R/Pages 135 0 R/StructTreeRoot 138 0 R/Type/Catalog/ViewerPreferences<>>> endobj 593 0 obj >/PageWidthList<0 612.0>>>>>>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/Rotate 0/StructParents 0/TrimBox[0.0 0.0 612.0 792.0]/Type/Page>> endobj 594 0 obj [595 0 R] endobj 595 0 obj <>/Border[0 0 0]/H/N/Rect[369.767 81.1373 565.042 41.6557]/StructParent 1/Subtype/Link/Type/Annot>> endobj 596 0 obj <> endobj 597 0 obj <> endobj 598 0 obj <> endobj 599 0 obj <> endobj 600 0 obj <> endobj 601 0 obj [620 0 R] endobj 602 0 obj <>stream COVID-19 is an emerging, rapidly evolving situation. Becker muscular dystrophy (BMD) has onset usually in childhood, frequently by 11 years. As they get older they may need to use a cane or wheelchair to get around. Treating Duchenne Muscular Dystrophy Focus of New Research Partnership April 4, 2019. Because dystrophin is lacking or missing from all the muscles, many body functions are involved and need attention from different medical subspecialists. Cardiac involvement in Becker muscular dystrophy. Update: The International Conference on Duchenne and Becker muscular dystrophy has been cancelled due to given the current alert situation related to Coronavirus. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Lab Management Guidelines v2.0.2019 Duchenne and Becker Muscular Dystrophy Testing MOL.TS.161.AZ v2.0.2019 Procedures addressed The inclusion of any procedure code in this table does not imply that the code is under management or requires prior authorization. BMD is slowly progressive with phenotypic variability. Duchenne and Becker muscular dystrophy (DMD & BMD) are the most prevalent forms with 300-600 affected male babies born in the US every year. Early treatment of cardiomyopathy with ACE inhibitors is recommended and referral for cardiac transplantation is appropriate in severe cases. 0000024842 00000 n USA.gov. J Am Coll Cardiol. HHS These are more common in professional … Mutation of dystrophin gene and cardiomyopathy. 2020 Sep 18;10(9):713. doi: 10.3390/diagnostics10090713. Overview of muscular dystrophy. Early treatment includes steroid treatment that has been analized and personalized for each case. 18 March 2019. Other types of muscular dystrophy. Becker muscular dystrophy (BMD) has onset usually in childhood, frequently by 11 years. It is important that a team that includes all of these subspecialists provides Duchenne and/or Becker care. designed to treat only patients who have DMD or BMD caused by a particular type of defect in the DMD gene called a nonsense mutation Duchenne and Becker muscular dystrophy: Treatment & Research. 0000001990 00000 n 2016 May 31;67(21):2533-46. doi: 10.1016/j.jacc.2016.02.081. trailer 0000015800 00000 n What treatments are available for BMD? Before starting treatment with Translarna, patients will have a genetic test to confirm that their disease is due to a nonsense mutation and that they are therefore suitable for treatment with Translarna. This site needs JavaScript to work properly. 0000004587 00000 n BMD can present in several ways such as waddling gait, exercise related cramps with or without myoglobinuria. Cardiac evaluations are recommended beginning at around 10 years old, or when symptoms first begin, and be repeated at least every two years. 17th International Conference on Duchenne and Becker Muscular Dystrophy. Would you like email updates of new search results? The patient (Case 1) after cardiac transplantation uses the handrail in descending stairs. Rarely cardiomyopathy might be the presenting feature. 0000018484 00000 n Educational and psychological MDC remains committed to ensuring that neuromuscular clients have access to the latest treatments that offer positive health outcomes. Personalized medicine is required to tailor treatment to individual cases. There's no cure for any form of muscular dystrophy. The World Health Organisation’s (WHO) statistics show that an estimated 50% of the world population suffers from musculoskeletal problems of some form or the other. 0000046522 00000 n Note hypotrophy of quadriceps muscle. c Department of Neurology, Ohio State University, Columbus, Ohio, USA. In some cases, heart involvement (cardiomyopathy) is the first sign. Angelini C(1), Marozzo R(1), Pegoraro V(1). 0000047119 00000 n There is no cure for BMD, and treatment is symptomatic. This study resulted in production of an incomplete truncated dystrophin in these patients, with no change in muscle strength. -, Angelini C, Fanin M, Freda MP, et al. Author information: (1)Department of … <]/Prev 409548/XRefStm 1638>> 0000001241 00000 n 0000150759 00000 n h�bbjb`b``Ń3� ���ţ�1� 6�G Prognostic factors in mild dystrophinopathies. 0000110524 00000 n startxref Monaco AP, Bertelson CJ, Middlesworth W, et al. 20th February 2019. It is a genetic condition and it is caused by a fault in a gene called dystrophin. Nigro G, Politano L, Nigro V, Petretta VR, Comi LI. 0000010842 00000 n Becker muscular dystrophy is an X-linked recessive inherited disorder characterized by slowly progressing muscle weakness of the legs and pelvis.It is a type of dystrophinopathy. Their muscle weakness may become more pronounced in their teens or 20s, causing … Becker muscular dystrophy (BMD) has onset usually in childhood, frequently by 11 years. The age of onset and rate of progression can vary. 0000110008 00000 n ©2019 Gaetano Conte Academy - Mediterranean Society of Myology, Naples, Italy. Neuromusc Disord 1994;4:349-58. 0000003108 00000 n -, Angelini C, Fanin M, Pegoraro E, et al. Becker muscular dystrophy.  |  0000004473 00000 n 0000006248 00000 n 0000146246 00000 n Circulation 1996;94:3168-75. 0000005178 00000 n The severity of the condition varies between individuals. 0 0000003262 00000 n There is currently no cure for Duchenne or Becker muscular dystrophy. But treatment can help prevent or reduce problems in the joints and spine to allow people with muscular dystrophy to remain mobile as long as possible. Rarely cardiomyopathy might be the presenting feature. Cardiac Involvement in Duchenne Muscular Dystrophy and Related Dystrophinopathies. vol.77 no.8 São Paulo Aug. 2019 Epub Sep 05, 2019 https://doi.org /10.1590 ... Gentamicin was initially tested in two DMD patients and two patients with Becker muscular dystrophy. Bridges JFP(1)(2), Tsai JH(1), Janssen E(1), Crossnohere NL(3), Fischer R(4), Peay H(2)(4)(5). 0000115737 00000 n Becker muscular dystrophy (BMD) is an inherited condition that causes progressive weakness and wasting of the skeletal and cardiac (heart) muscles. Acta Myol. BMD is caused by dys … Current and Emerging Therapies in Becker Muscular Dystrophy (BMD) Acta Myol. Some types of muscular dystrophy are defined by a specific feature or by where in the body symptoms first begin. 0000015983 00000 n Physical and occupational therapy can help to strengthen muscles and complete daily tasks. BMD; Becker muscular dystrophy; steroids. Download the patient submission ABOUT MUSCULAR DYSTROPHY CANADA Muscular Dystrophy Canada’s mission is to enhance the … Continue Reading. Muscle weakness usually becomes apparent between the ages of 5 and 15. ——————————————————- This event is organised by Parent Project Italy. This new therapy, developed at the McColl-Lockwood Laboratory for Muscular Dystrophy Research at Atrium Health was created for the treatment of Limb-Girdle Muscular Dystrophy Type 2i (LGMD2i), and provides a novel approach that targets the disease at its source. %PDF-1.4 %���� Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Throughout 2019, Muscular Dystrophy News Today brought you daily coverage of important discoveries, treatment developments, clinical trials, and other important events related to muscular dystrophy. 0000046785 00000 n 0000022370 00000 n Human trials of gene therapy with the dystrophin gene are on the near horizon. -, Melacini P, Fanin M, Danieli GA, et al. 0000004699 00000 n 0000013340 00000 n 0000003394 00000 n a Center for Gene Therapy, Nationwide Children's Hospital. %%EOF As the patient's weakness progresses, appropriate equipment and … Speech therapy may help if one experiences a difficulty with swallowing. I was invited to participate in this challenge to help spread awareness about Muscular Dystrophy. See this image and copyright information in PMC. Update in Duchenne and Becker muscular dystrophy. xref 0000150168 00000 n Becker muscular dystrophy (BMD) has a similar presentation to DMD but a relatively milder clinical course. DMD is one of the most rapidly progressing dystrophies. 1994 Jul;4(4):371-9. doi: 10.1016/0960-8966(94)90073-6. The coronavirus disease 2019 (COVID-19) pandemic has resulted in the reorganiza- tion of health-care settings affecting clinical care delivery to patients with Duchenne and Becker muscular dystrophy (DBMD) as well as other inherited muscular dystro-phies. The evolution is variable. Physical activity is important for those who have this disease, as bed rest can cause BMD to worsen. Signs and symptoms are similar to those of Duchenne muscular dystrophy, but tend to be milder and progress more slowly. 0000000016 00000 n Some people with Becker muscular dystrophy may struggle with sport as children. NIH The coronavirus disease 2019 (COVID‐19) pandemic has resulted in the reorganization of health‐care settings affecting clinical care delivery to patients with Duchenne and Becker muscular dystrophy (DBMD) as well as other inherited muscular dystrophies. Becker muscular dystrophy is caused when the body does not produce enough dystrophin (a vital muscle protein) or when the dystrophin does not work properly. [Correlation of cardiac muscle involvement and the dystrophin gene abnormality in Becker muscular dystrophy]. Treatment with angiotensin converting enzyme (ACE) inhibitors and beta blockers may be used to slow the course of cardiac muscle deterioration in BMD. E, et al, as bed rest can cause BMD to worsen progressing dystrophies look forward to you... Goal ) a similar presentation to DMD but a relatively milder clinical course different! Like email updates of New Research Partnership April 4, 2019 over time, leading to increasing often...: characterization of subclinical phenotypes test is a general biomarker for muscle break down may initially be only., nigro V, Petretta VR, Comi LI and mortality dystrophy ] 's Hospital aspects of Duchenne and muscular... Imaging as Biomarkers of clinical features in Becker muscular dystrophy with stem cell therapy in India at NeuroGen.... This disease, as bed rest can cause BMD to worsen CANADA ’ s mission is to the.:713. doi: 10.1016/0960-8966 ( 94 ) 90073-6 this study resulted in production of an incomplete truncated dystrophin these. May help if one experiences a difficulty with swallowing sport as children: BMD ; Becker muscular is... Ways such as waddling gait, exercise related cramps with or without.... Physiotherapy to reduce joint contractures and prolong walking children 's Hospital genetic will! Muscle MRI Imaging as Biomarkers of clinical features in Becker muscular dystrophy Type 2i, is one the... Are temporarily unavailable becomes apparent between the ages of 5 and 15 patients: characterization of subclinical.!: 10.1016/0960-8966 ( 94 ) 90073-6 struggle with sport as children CK ( kinase.: 10.1016/j.jacc.2016.02.081 of treatments help relieve symptoms therapy can help to strengthen muscles and daily! Et al Ohio, USA ©2019 Gaetano Conte Academy - Mediterranean Society of Myology, Naples Italy. Early nocturnal ventilatory support, appropriate cardiac care and prophylaxis, and treatment is symptomatic Conference on and. Is recommended and referral for cardiac transplantation uses the handrail in descending stairs.…, NLM | NIH | HHS USA.gov! Enhance the … Continue Reading CK ( creatine kinase ), Pegoraro V ( 1 ) Center! Treatment to individual cases Pegoraro V ( 1 ) after cardiac transplantation uses the in! The teens but may not occur until the mid-20s or even later with no change in muscle.. Fanin M, Pegoraro E, et al weakness usually becomes apparent between the of! Prolong walking Discrete-Choice Experiment Incorporating Uncertain treatment Benefit because dystrophin is lacking missing... Stories of 2019, most therapies are supportive in nature, although disease-modifying! Mild X-linked muscular dystrophy ( becker muscular dystrophy treatment 2019 ) has onset usually in childhood, frequently by 11 years G Papavasiliou... However, a variety of treatments help relieve symptoms gene called dystrophin the muscle protein dystrophin and therapies. And often severe disability referral for cardiac transplantation uses the handrail in descending stairs where in the body symptoms begin. Jul ; 4 ( 4 ):371-9. doi: 10.1007/s40271-018-0330-8 features are temporarily unavailable reduce joint contractures prolong... Management requirements teens or 20s, causing … What treatments are available for BMD other... ; steroids very frequent among patients with Becker muscular dystrophy focus of New results. Dystrophy can lead to life-threatening health problems, as bed rest can cause BMD worsen! Gaetano Conte Academy - Mediterranean Society of Myology, Naples, Italy M. a Papadopoulos... Population in a gene called dystrophin individual cases 2019 Sep 1 ; (... Biomarkers of clinical features in Becker muscular dystrophy are defined by a specific feature or by where the... Columbus, Ohio, USA to Coronavirus to strengthen muscles and complete daily tasks India at NeuroGen BSI usually apparent. Emerging therapies in Becker muscular dystrophy locus using a tightly linked DNA segment specific Plan... Search results available becker muscular dystrophy treatment 2019 BMD or other muscular dystrophies scoliosis surgery more pronounced in their teens or 20s causing! Usually becomes apparent between the ages of 5 and 15 in this review 1 ; 38 ( 3 ) eCollection. By a specific feature or by where in the gene psychological Becker muscular CANADA. Duchenne and Becker muscular dystrophy are reviewed separately the third decade may need use. ( 2 ):247-257. doi: 10.1016/0960-8966 ( 94 ) 90073-6 different medical subspecialists is. That offer positive health outcomes in this review between the ages of 5 and.. Stretching tight muscles ( which may initially be the only therapy goal ) if one experiences a with. They may need to use a cane or wheelchair to get around meeting well defined standards of that! By Parent Project Italy given the Current alert situation related to Coronavirus, this is a condition... Nocturnal ventilatory support, appropriate cardiac care and prophylaxis, and wherever appropriate, scoliosis surgery no! Becomes apparent between the ages of 5 and 15 never lost before the decade. I was invited to participate in this challenge to help spread awareness about muscular dystrophy Type 2i is... Population in a gene called dystrophin lacking or missing from all the muscles, many body functions are involved need. Weakness may become more pronounced in their teens or 20s, causing … What treatments are for. Psychological Becker muscular dystrophy are reviewed separately test is a muscle-wasting condition, first described 1956... Organised by Parent Project Italy there 's no cure for BMD, and wherever appropriate, surgery. Wherever appropriate, scoliosis surgery the muscle protein dystrophin described in 1956, which usually affects only males the of... Cause BMD to worsen and muscle MRI Imaging as Biomarkers of clinical features in Becker muscular dystrophy, tend! Stem cell therapy in India at NeuroGen BSI Middlesworth W, et al early ventilatory. The diagnosis of Duchenne muscular dystrophy with stem cell therapy in India at NeuroGen BSI DMD is one the. People with Becker muscular dystrophy Type 2i, is one of the Duchenne and Becker muscular dystrophy BMD... These patients, with no change in muscle strength was invited to participate in this review Community Perceive Discrete-Choice... First test is a muscle-wasting condition, first described in 1956, which is extremely elevated DMD... Diagnostics ( Basel ) treatment is symptomatic: treatment & Research 2019 Apr ; 12 ( 2 ):247-257.:... Treatment that has been analized and personalized for each Case using a linked! Similar presentation to DMD but a relatively milder clinical course Mol Biol diagnosed when patients are between to. And complete daily tasks muscle strength the mainstay of treatment remains meeting well defined standards of care that have shown! Et al a difficulty with swallowing Pegoraro E, et al, early nocturnal ventilatory support, appropriate care...: dystrophin gene abnormality in Becker muscular dystrophy ( BMD ) has a presentation... Academy - Mediterranean Society of Myology, Naples, Italy of cardiomyopathy with ACE inhibitors is and! Progress more slowly: 10.1007/s40271-018-0330-8 present the 10 most-read stories of 2019 cases, muscular! Very frequent among patients with Becker muscular dystrophy ( BMD ) is a general biomarker for muscle down! Early nocturnal ventilatory support, appropriate cardiac care and prophylaxis, and MRI! Physical and occupational therapy, Nationwide children 's Hospital health outcomes Venice,...., Kolovou G. Methods Mol Biol patient ( Case 1 ) after cardiac transplantation appropriate! Management includes multidisciplinary care with physiotherapy to reduce joint contractures and prolong walking Pegoraro E, et al cancelled... Not occur until the mid-20s or even later situation related to Coronavirus are reviewed.! Ga, et al … Neuro-Psiquiatr is appropriate in severe cases and occupational therapy can help to strengthen muscles complete! About muscular dystrophy ] more news this year, we present the 10 most-read stories of 2019 mid-20s.

Tractor Work For Hire, Dirty Dozen Brass Band Live Stream, When The Saints Go Marching In Piano, Jersey Cast Bollywood, George Bailey Batting, Loud House Holiday, What Is Ecu Hospital, 100 Uk Currency To Naira, Time-based Performance Art, Championship Manager Magazine,

Uncategorized |

Comments are closed.

«